Cancer Care through Early Detection & Intervention: NFCR

Clinical Research and Trial Platforms

Clinical Research and Trial Platforms

What is Clinical Research and Trial Platforms?

Conducting rigorous clinical trials is essential for evaluating the safety and efficacy of new cancer therapies, screening tests, and prevention approaches before they can be approved for widespread use. Novel clinical trial designs and research platforms are continuously being developed to accelerate this process.

Innovations in clinical research include enrichment strategies selecting patients most likely to respond, adaptive trials modifying parameters based on interim data, master protocols evaluating multiple therapies simultaneously, and platform trials rapidly screening multiple candidate treatments. These approaches aim to increase trial efficiency, minimize patient burden, and identify optimal treatments faster. 

NFCR-Supported Researchers Working on Clinical Research and Trial Platforms

Manijeh Goldberg, Ph.D., University of Massachusetts

Manijeh Goldberg, Ph.D.
University of Massachusetts

Cesare Spadoni, Ph.D., M.B.A.
University of London

Ronald A. DePinho, M.D.
University of Texas MD Anderson Cancer Center

Yung-Chi Cheng, Ph.D.

Yung-Chi Cheng, Ph.D.
Yale University

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Longest Living GBM Cancer Survivor Celebrates 20 Years Cancer-Free

Twenty years ago, Carmen Rice was told to get her affairs in order, she was diagnosed with the deadliest form of brain cancer, glioblastoma. At the time, she was told she had about 6 months to live. In what she believes to be a miracle, in 2024, Carmen celebrated 20-years being cancer free from glioblastoma. Overall, glioblastoma has a five-year survival rate less than 8%. Carmen Rice is considered the longest living glioblastoma (GBM) cancer survivor. What Makes GBM so deadly? GBM is one of the deadly cancers that has seen very few significant updates over the last 20 years. The lack of breakthroughs is not because researchers aren’t trying – they are – but because there is a bottleneck at the clinical trial stage to approve better treatments. How is NFCR Addressing this Deadly Form of Cancer? GBM AGILE is a revolutionary clinical trial platform designed for patients battling the deadliest brain cancer, glioblastoma. The AGILE trial design is a model for drug development to support patients with other rare cancers and diseases. NFCR CEO, Dr. Sujuan Ba is a founding member leading the charge to get GBM AGILE started and NFCR provided early funding that made it all possible. Now, the innovative GBM AGILE trial platform continues to expand and improve outcomes for the most difficult-to-treat cancers, including GBM, Ovarian, and Pancreatic Cancers. Learn more about GBM AGILE here. Glioblastoma (GBM) is the deadliest type of brain cancer, accounting for 45% of all primary malignant brain tumors. Hope for the Future of Surviving Other Deadly Cancer The miracle of Carmen’s survival is what NFCR supported scientists are working to secure for every cancer patient. We hope that her story of challenging the odds and survival reminds all patients and supporters there is hope for a better future. “I have found the National Foundation for Cancer Research team to be dedicated and caring, I have been treated as part of their family.  I feel privileged to have met them.  I know that one day my fine and dedicated family will find a cure for glioblastoma and many other cancers and save the lives of people like me.  I am delighted to know that they work on a global scale to find a cure for glioblastoma.  They give me hope and inspiration to move forward!”    - Carmen Rice To make a gift today in honor of cancer survivors like Carmen, please donate here. Carmen’s recovery inspired her to write about her experiences with battling cancer and the road to remission. The book titled, They Call Me “The Miracle“, is a collaboration between talented writer Randy Harris and cancer survivor Carmen Rice, focused on bringing hope to those who are battling illness or doubt in their own lives. Order her book here, and NFCR will receive a portion of your purchase from Amazon!

NFCR Congratulates GCAR on its New Partnership & GBM AGILE Expansion

The National Foundation for Cancer Research (NFCR) and CEO Sujuan Ba, Ph.D., congratulate the Global Coalition for Adaptive Research (GCAR) for their continued commitment to expanding options for cancer patients and perseverance in the fight against difficult-to-treat cancers.  Recently, GCAR announced its strategic partnership with the Pancreatic Cancer Action Network (PANCAN) to accelerate treatment options for pancreatic cancer patients. In collaboration, GCAR and PANCAN will launch the next phase of their clinical trial. Pancreatic cancer is one of the few cancers for which survival has not improved substantially in over 40 years. It has proved difficult to diagnose in the early stages when cancer is most treatable. Consequently, the overall five-year survival rate for pancreatic cancer is just 12%. Pancreatic patients and their families deserve better. Dr. Ba is one of the few individuals who has been a part of GBM AGILE from the beginning, fighting for progress for cancer patients. Dr. Ba co-founded GBM AGILE, the innovative, paradigm-shifting clinical trial accelerating how we review and approve life-saving cancer treatments for the most difficult-to-treat cancers, such as glioblastoma (GBM). Part of the founding vision of GCAR was to expand the adaptive clinical trial approach beyond GBM. GCAR's alliance with PANCAN demonstrates they are taking the necessary steps to achieve this goal and provide great hope for cancer patients. From the Press Release: "GCAR is excited to collaborate with PanCAN to launch this innovative and groundbreaking effort, continuing to work with the clinicians, patient community and industry to move forward the vision to improve treatment options for patients," said Dr. Meredith Buxton, CEO & President, GCAR.  NFCR extends our kudos to both GCAR and PANCAN for their commitment to improving cancer survivorship!  {{ vc_btn: title=Read+The+Press+Release&style=custom&custom_background=%23002c76&custom_text=%23ffffff&align=center&button_block=true&link=url%3Ahttps%253A%252F%252Fwww.gcaresearch.org%252Fnews%252Fthe-pancreatic-cancer-action-network-and-the-global-coalition-for-adaptive-research-forge-a-powerful-alliance-to-accelerate-treatment-options-for-pancreatic-cancer-patients%252F%7Ctarget%3A_blank }}{{ vc_btn: title=Learn+More+about+GBM+AGILE&style=custom&custom_background=%23ff5012&custom_text=%23ffffff&align=center&button_block=true&link=url%3Ahttps%253A%252F%252Fwww.nfcr.org%252Fgbm-agile-2%252F%7Ctarget%3A_blank }} Cures for cancer are coming! Be a part of the movment to Make Cures Possible.

GBM Awareness Day – Make Cures Possible with NFCR

Today is GBM Awareness Day. GBM is one of the deadly cancers that has seen very few significant updates over the last 20 years. The lack of breakthroughs is not because researchers aren't trying - they are - but because there is a bottleneck at the clinical trial stage to approve better treatments. This bottleneck is one of the critical reasons NFCR, led by President & CEO Dr. Sujuan Ba, is committed to bringing new treatment options to patients through the GBM AGILE initiative. GBM AGILE is a paradigm-shifting clinical trial system. Our hope is that this can become the foundation for defeating other rare and complex cancers. GBM is the deadliest type of brain cancer, accounting for 45% of all malignant brain tumors and the five-year average survival rate is only 5% or less. Learn More about Brain Cancers. Dr. Ba is one of the few individuals who has been a part of GBM AGILE from the beginning, fighting for progress for cancer patients. "It is imperative that patients know we will not give up on them." NFCR Makes Cures Possible, and we intend to do the same for patients facing the deadliest brain cancer, GBM. GBM RESOURCES FROM NFCR Hope After a Glioblastoma Diagnosis Carmen Rice was given 6 months to live; 3 good, 3 bad. Over a decade later, she is still thriving and advocating for better options for other glioblastoma patients. Watch this video to better understand what glioblastoma patients are up against.  Caregiver Tips Tom and his wife Bernadette were happily living their daily life when they noticed Bernadette’s occasional fumbling for certain words or movements. Tom became his wife's caregiver and wants to share his tips and experience to help others in similar situations. GBM AGILE Learn more about the paradigm-shifting clinical trial system that efficiently tests new treatments, advancing effective ones faster and rejecting ineffective ones quickly.